Reaction Details |
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Target | 26S proteasome non-ATPase regulatory subunit 14 |
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Ligand | BDBM83218 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay |
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IC50 | 1770±224 nM |
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Citation | PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID] |
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More Info.: | Get all data from this article, Assay Method |
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26S proteasome non-ATPase regulatory subunit 14 |
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Name: | 26S proteasome non-ATPase regulatory subunit 14 |
Synonyms: | 26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein |
Type: | Protein |
Mol. Mass.: | 34576.68 |
Organism: | Homo sapiens (Human) |
Description: | O00487 |
Residue: | 310 |
Sequence: | MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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BDBM83218 |
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n/a |
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Name | BDBM83218 |
Synonyms: | 1-[(Z)-3-indolylidenemethyl]-2-(4-nitrophenyl)hydrazine | 1-[(Z)-indol-3-ylidenemethyl]-2-(4-nitrophenyl)diazane | 1-[(Z)-indol-3-ylidenemethyl]-2-(4-nitrophenyl)hydrazine | 1H-indole-3-carbaldehyde (4-nitrophenyl)hydrazone | MLS000573812 | SMR000184664 | cid_5718086 |
Type | Small organic molecule |
Emp. Form. | C15H12N4O2 |
Mol. Mass. | 280.2814 |
SMILES | [O-][N+](=O)c1ccc(cc1)N=[NH+]Cc1c[n-]c2ccccc12 |w:10.11| |
Structure |
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