| Reaction Details |
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 | Report a problem with these data |
| Target | 26S proteasome non-ATPase regulatory subunit 14 |
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| Ligand | BDBM88869 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay |
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| IC50 | 1410±359 nM |
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| Citation |  PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| 26S proteasome non-ATPase regulatory subunit 14 |
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| Name: | 26S proteasome non-ATPase regulatory subunit 14 |
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| Synonyms: | 26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein |
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| Type: | Protein |
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| Mol. Mass.: | 34576.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00487 |
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| Residue: | 310 |
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| Sequence: | MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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| BDBM88869 |
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| n/a |
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| Name | BDBM88869 |
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| Synonyms: | 2-N,4-N-bis[(E)-(3-methoxyphenyl)methylideneamino]-3,5-dimethyl-1H-pyrrole-2,4-dicarboxamide | MLS000585379 | N'~2~,N'~4~-bis[(1E)-(3-methoxyphenyl)methylene]-3,5-dimethyl-1H-pyrrole-2,4-dicarbohydrazide | N,N'-bis[(E)-m-anisylideneamino]-3,5-dimethyl-1H-pyrrole-2,4-dicarboxamide | N2,N4-bis[(E)-(3-methoxyphenyl)methylideneamino]-3,5-dimethyl-1H-pyrrole-2,4-dicarboxamide | SMR000204142 | cid_20846841 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25N5O4 |
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| Mol. Mass. | 447.4864 |
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| SMILES | COc1cccc(\C=N\NC(=O)c2[nH]c(C)c(C(=O)N\N=C\c3cccc(OC)c3)c2C)c1 |
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| Structure | 
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