Reaction Details |
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Target | 26S proteasome non-ATPase regulatory subunit 14 |
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Ligand | BDBM76125 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay |
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IC50 | 7640±1740 nM |
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Citation | PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID] |
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More Info.: | Get all data from this article, Assay Method |
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26S proteasome non-ATPase regulatory subunit 14 |
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Name: | 26S proteasome non-ATPase regulatory subunit 14 |
Synonyms: | 26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein |
Type: | Protein |
Mol. Mass.: | 34576.68 |
Organism: | Homo sapiens (Human) |
Description: | O00487 |
Residue: | 310 |
Sequence: | MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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BDBM76125 |
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n/a |
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Name | BDBM76125 |
Synonyms: | (3-butyl-7-methyl-6,8-dioxoisochromen-7-yl) cyclopentanecarboxylate | CMLD003384 | MLS000438302 | SMR000452562 | [3-butyl-7-methyl-6,8-bis(oxidanylidene)isochromen-7-yl] cyclopentanecarboxylate | cid_16745542 | cyclopentanecarboxylic acid (3-butyl-6,8-diketo-7-methyl-isochromen-7-yl) ester | cyclopentanecarboxylic acid (3-butyl-7-methyl-6,8-dioxo-2-benzopyran-7-yl) ester |
Type | Small organic molecule |
Emp. Form. | C20H24O5 |
Mol. Mass. | 344.4016 |
SMILES | CCCCC1=CC2=CC(=O)C(C)(OC(=O)C3CCCC3)C(=O)C2=CO1 |c:24,t:4,6| |
Structure |
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