Ki Summary

Reaction Details

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Target

26S proteasome non-ATPase regulatory subunit 14

Ligand

BDBM89023

Substrate/Competitor

n/a

Meas. Tech.

Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay

IC50

7920±482 nM

Citation

PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID]

More Info.:

Get all data from this article, Assay Method

26S proteasome non-ATPase regulatory subunit 14

Name:

26S proteasome non-ATPase regulatory subunit 14

Synonyms:

26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein

Type:

Protein

Mol. Mass.:

34576.68

Organism:

Homo sapiens (Human)

Description:

O00487

Residue:

310

Sequence:

MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK

BDBM89023

n/a

Name

BDBM89023

Synonyms:

6-[(5Z)-4-keto-5-[[1-phenyl-3-(2-thienyl)pyrazol-4-yl]methylene]-2-thioxo-thiazolidin-3-yl]hexanoic acid | 6-[(5Z)-4-oxidanylidene-5-[(1-phenyl-3-thiophen-2-yl-pyrazol-4-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid | 6-[(5Z)-4-oxo-5-[(1-phenyl-3-thiophen-2-yl-4-pyrazolyl)methylidene]-2-sulfanylidene-3-thiazolidinyl]hexanoic acid | 6-[(5Z)-4-oxo-5-[(1-phenyl-3-thiophen-2-ylpyrazol-4-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid | MLS002633376 | SMR001544447 | cid_1632449

Type

Small organic molecule

Emp. Form.

C23H21N3O3S3

Mol. Mass.

483.626

SMILES

OC(=O)CCCCCN1C(=S)S\C(=C/c2cn(nc2-c2cccs2)-c2ccccc2)C1=O

Structure