| Reaction Details |
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 | Report a problem with these data |
| Target | Prothrombin |
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| Ligand | BDBM83506 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay |
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| IC50 | 148±17 nM |
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| Citation |  PubChem, PC Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| Prothrombin |
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| Name: | Prothrombin |
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| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | THRB_BOVIN | Thrombin | Thrombin heavy chain | Thrombin light chain |
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| Type: | Enzyme |
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| Mol. Mass.: | 70502.73 |
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| Organism: | Bos taurus (Bovine) |
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| Description: | P00735 |
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| Residue: | 625 |
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| Sequence: | MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERE
CLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGN
VSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRRE
ECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSS
EQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDL
GDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFE
SYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNF
TVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDY
IHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCK
ASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRD
GKYGFYTHVFRLKKWIQKVIDRLGS
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| BDBM83506 |
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| n/a |
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| Name | BDBM83506 |
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| Synonyms: | (5Z)-5-[[2-(3-isopropoxypropylamino)-4-keto-9-methyl-pyrido[1,2-a]pyrimidin-3-yl]methylene]-3-propyl-2-thioxo-thiazolidin-4-one | (5Z)-5-[[9-methyl-4-oxidanylidene-2-(3-propan-2-yloxypropylamino)pyrido[1,2-a]pyrimidin-3-yl]methylidene]-3-propyl-2-sulfanylidene-1,3-thiazolidin-4-one | (5Z)-5-[[9-methyl-4-oxo-2-(3-propan-2-yloxypropylamino)-3-pyrido[1,2-a]pyrimidinyl]methylidene]-3-propyl-2-sulfanylidene-4-thiazolidinone | (5Z)-5-[[9-methyl-4-oxo-2-(3-propan-2-yloxypropylamino)pyrido[1,2-a]pyrimidin-3-yl]methylidene]-3-propyl-2-sulfanylidene-1,3-thiazolidin-4-one | 2-(3-Isopropoxy-propylamino)-9-methyl-3-[4-oxo-3-propyl-2-thioxo-thiazolidin-(5Z)-ylidenemethyl]-pyrid o[1,2-a]pyrimidin-4-one | MLS000556879 | SMR000147996 | cid_1880983 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H28N4O3S2 |
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| Mol. Mass. | 460.613 |
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| SMILES | CCCN1C(=S)S\C(=C/c2c(NCCCOC(C)C)nc3c(C)cccn3c2=O)C1=O |
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| Structure | 
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