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Reaction Details
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TargetHigh-affinity choline transporter
LigandBDBM79705
Substrate/Competitorn/a
Meas. Tech.Dose responses of compounds that activate the Choline Transporter (CHT) - 10 point CRC
EC50 8240±n/a nM
Citation PubChem PC Dose responses of compounds that activate the Choline Transporter (CHT) - 10 point CRC PubChem Bioassay (2012)[AID]
More Info.:Get all data from this article,  Assay Method
 
High-affinity choline transporter
Name:High-affinity choline transporter
Synonyms:high affinity choline transporter 1
Type:PROTEIN
Mol. Mass.:63194.33
Organism:Homo sapiens (Human)
Description:ChEMBL_1464247
Residue:580
Sequence:
MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTA
TWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQ
IYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGG
LYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSW
LDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDW
NQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFA
RNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQ
LLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFK
TLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLD
ELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM79705
n/a
NameBDBM79705
Synonyms:2-(4-{[1-(5-chloropyridin-2-yl)-1H-pyrrol-2-yl]methyl}-1-isobutylpiperazin-2-yl)ethanol | 2-[4-[[1-(5-chloranylpyridin-2-yl)pyrrol-2-yl]methyl]-1-(2-methylpropyl)piperazin-2-yl]ethanol | 2-[4-[[1-(5-chloro-2-pyridinyl)-2-pyrrolyl]methyl]-1-(2-methylpropyl)-2-piperazinyl]ethanol | 2-[4-[[1-(5-chloro-2-pyridyl)pyrrol-2-yl]methyl]-1-isobutyl-piperazin-2-yl]ethanol | 2-[4-[[1-(5-chloropyridin-2-yl)pyrrol-2-yl]methyl]-1-(2-methylpropyl)piperazin-2-yl]ethanol | MLS000733260 | SMR000315885 | cid_16187269
TypeSmall organic molecule
Emp. Form.C20H29ClN4O
Mol. Mass.376.923
SMILESCC(C)CN1CCN(Cc2cccn2-c2ccc(Cl)cn2)CC1CCO
Structure
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