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TargetInterleukin-1 receptor-associated kinase 4
LigandBDBM278709
Substrate/Competitorn/a
Meas. Tech.IRAK4 Kinase Assay
pH7.2±n/a
IC50 1.000±n/a nM
Commentsextracted
Citation Lim JAltman MDBrubaker JDGibeau CR Pyrrolopyridazine inhibitors of IRAK4 activity US Patent  US10040798 Publication Date 8/7/2018
More Info.:Get all data from this article,  Assay Method
 
Interleukin-1 receptor-associated kinase 4
Name:Interleukin-1 receptor-associated kinase 4
Synonyms:IRAK-4 | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:Protein
Mol. Mass.:51519.08
Organism:Homo sapiens (Human)
Description:Q9NWZ3
Residue:460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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BDBM278709
n/a
NameBDBM278709
Synonyms:N-[1-methyl-3- (trifluoromethyl)-1H- pyrazol-4-yl]-2-[(3R)- piperidin-3- ylamino]pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate | US10040798, Example 6
TypeSmall organic molecule
Emp. Form.C20H21F6N7O3
Mol. Mass.521.4163
SMILESOC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCNC4)nn23)c(n1)C(F)(F)F |r|
Structure
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