Reaction Details |
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Target | Interleukin-1 receptor-associated kinase 4 |
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Ligand | BDBM278777 |
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Substrate/Competitor | n/a |
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Meas. Tech. | IRAK4 Kinase Assay |
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pH | 7.2±n/a |
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IC50 | 2.00±n/a nM |
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Comments | extracted |
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Citation | Lim, J; Altman, MD; Brubaker, JD; Gibeau, CR Pyrrolopyridazine inhibitors of IRAK4 activity US Patent US10040798 Publication Date 8/7/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Interleukin-1 receptor-associated kinase 4 |
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Name: | Interleukin-1 receptor-associated kinase 4 |
Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
Type: | Protein |
Mol. Mass.: | 51519.08 |
Organism: | Homo sapiens (Human) |
Description: | Q9NWZ3 |
Residue: | 460 |
Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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BDBM278777 |
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n/a |
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Name | BDBM278777 |
Synonyms: | 2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(2-cyanothiophen- 3-yl)pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate | US10040798, Example 75 |
Type | Small organic molecule |
Emp. Form. | C21H21F3N6O3S |
Mol. Mass. | 494.49 |
SMILES | OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccsc3C#N)n2n1 |r| |
Structure |
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