Reaction Details | |||
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Target | DNA dC->dU-editing enzyme APOBEC-3G | ||
Ligand | BDBM60611 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2 | ||
Temperature | 298.15±n/a K | ||
IC50 | 732±n/a nM | ||
Comments | extracted | ||
Citation | PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2 PubChem Bioassay(2012)[AID] | ||
More Info.: | Get all data from this article, Assay Method | ||
DNA dC->dU-editing enzyme APOBEC-3G | |||
Name: | DNA dC->dU-editing enzyme APOBEC-3G | ||
Synonyms: | ABC3G_HUMAN | APOBEC3G | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 46419.54 | ||
Organism: | Homo sapiens (Human) | ||
Description: | gi_13399304 | ||
Residue: | 384 | ||
Sequence: |
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BDBM60611 | |||
n/a | |||
Name | BDBM60611 | ||
Synonyms: | (4E)-2-methoxy-4-[[[3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-5-thioxo-1H-1,2,4-triazol-4-yl]amino]methylene]cyclohexa-2,5-dien-1-one | (4E)-2-methoxy-4-[[[5-sulfanylidene-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-1H-1,2,4-triazol-4-yl]amino]methylidene]-1-cyclohexa-2,5-dienone | (4E)-2-methoxy-4-[[[5-sulfanylidene-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-1H-1,2,4-triazol-4-yl]amino]methylidene]cyclohexa-2,5-dien-1-one | 4-{[(E)-3-Mercapto-5-(1,4,5,6-tetrahydro-cyclopentapyrazol-3-yl)-[1,2,4]triazol-4-ylimino]-methyl}-2-methoxy-phenol | MLS000331417 | SMR000220894 | cid_16189647 | ||
Type | Small organic molecule | ||
Emp. Form. | C16H16N6O2S | ||
Mol. Mass. | 356.402 | ||
SMILES | COc1cc(C=Nn2c(n[nH]c2=S)-c2n[nH]c3CCCc23)ccc1O |w:6.6| | ||
Structure |