Reaction Details |
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Target | Deoxyuridine 5'-triphosphate nucleotidohydrolase |
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Ligand | BDBM50173567 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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pH | 8±0 |
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Temperature | 298.15±0 K |
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Ki | 6.28e+3±n/a nM |
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Citation | Musso-Buendía, JA; Vidal, AE; Kasinthan, G; Nguyen, C; Carrero-Lérida, J; Ruiz-Pérez, LM; Wilson, K; Johansson, NG; Gilbert, IH; González-Pacanowska, D Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni. J Enzyme Inhib Med Chem24:111-6 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Deoxyuridine 5'-triphosphate nucleotidohydrolase |
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Name: | Deoxyuridine 5'-triphosphate nucleotidohydrolase |
Synonyms: | dUTP pyrophosphatase |
Type: | Protein |
Mol. Mass.: | 19574.43 |
Organism: | Plasmodium falciparum |
Description: | Q8II92 |
Residue: | 173 |
Sequence: | MHLKIVCLSDEVREMYKNHKTHHEGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKS
NYYYKCEKSENKKKDDDKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAAL
DNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGSTSNNKY
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BDBM50173567 |
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n/a |
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Name | BDBM50173567 |
Synonyms: | 1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-fluoro-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione | CHEMBL195997 | dUTPase inhibitor, 6 |
Type | Small organic molecule |
Emp. Form. | C15H25FN2O4Si |
Mol. Mass. | 344.4539 |
SMILES | CC(C)(C)[Si](C)(C)OCC1OC(CC1F)n1ccc(=O)[nH]c1=O |
Structure |
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