Ki Summary

Reaction Details

Report a problem with these data

Target

Serine/threonine-protein kinase Chk1

Ligand

BDBM91889

Substrate/Competitor

n/a

Meas. Tech.

ChemBL affinity - Published Abbott papers

501±n/a nM

Citation

CSARdock, CD CHK1 in CSAR_FULL_RELEASE_3JULY2012 CSAR1:0 (2012)

More Info.:

Get all data from this article, Solution Info, Assay Method

Serine/threonine-protein kinase Chk1

Name:

Serine/threonine-protein kinase Chk1

Synonyms:

CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

54443.02

Organism:

Homo sapiens (Human)

Description:

gi_166295192

Residue:

476

Sequence:

MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT

BDBM91889

n/a

Name

BDBM91889

Synonyms:

Chk1_24

Type

n/a

Emp. Form.

C28H29N3O

Mol. Mass.

423.5494

SMILES

CC1CCC(CC1)NCc1ccc-2c(Cc3c(n[nH]c-23)-c2ccc3cc(O)ccc3c2)c1 |(-8.72,1.74,;-7.22,1.4,;-6.17,2.52,;-4.67,2.17,;-4.22,.7,;-5.27,-.43,;-6.77,-.08,;-2.72,.35,;-1.67,1.47,;-.17,1.12,;.28,-.35,;1.78,-.7,;2.83,.42,;2.39,1.89,;3.65,2.77,;4.88,1.84,;6.42,1.81,;6.86,.34,;5.6,-.54,;4.37,.39,;7.35,3.04,;6.75,4.46,;7.68,5.69,;9.21,5.5,;10.14,6.73,;11.66,6.53,;12.59,7.76,;12.26,5.12,;11.33,3.89,;9.8,4.08,;8.88,2.85,;.89,2.24,)|

Structure