| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
|---|
| Ligand | BDBM279112 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PDE1 Inhibition Assay |
|---|
| pH | 7.6±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 3.80±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgård, M; Rasmussen, LK; Clementson, CM 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors US Patent US10034861 Publication Date 7/31/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
|---|
| Name: | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
|---|
| Synonyms: | 61 kDa Cam-PDE | Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A | Cam-PDE 1A | PDE1A | PDE1A_HUMAN | hCam-1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 61245.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P54750 |
|---|
| Residue: | 535 |
|---|
| Sequence: | MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA
SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS
IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI
YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI
MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL
ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS
MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ
|
|
|
|---|
| BDBM279112 |
|---|
| n/a |
|---|
| Name | BDBM279112 |
|---|
| Synonyms: | 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine | US10034861, Example 143 | US10512632, Example 143 | US10766893, Example S143 | US10806718, Example 143 | US11026923, Example 143 | US11491140, Example 143 | US11634416, Example 143 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H27N7O |
|---|
| Mol. Mass. | 405.4961 |
|---|
| SMILES | CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
