Reaction Details |
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Target | Hypoxanthine-guanine-xanthine phosphoribosyltransferase |
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Ligand | BDBM92357 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhbition Assay |
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pH | 7.6±0 |
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Temperature | 310.15±0 K |
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Ki | 10.6±1.3 nM |
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Citation | Hazleton, KZ; Ho, MC; Cassera, MB; Clinch, K; Crump, DR; Rosario, I; Merino, EF; Almo, SC; Tyler, PC; Schramm, VL Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase. Chem Biol19:721-30 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Hypoxanthine-guanine-xanthine phosphoribosyltransferase |
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Name: | Hypoxanthine-guanine-xanthine phosphoribosyltransferase |
Synonyms: | HGXR_PLAFG | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) | Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT) | LACZ |
Type: | Protein |
Mol. Mass.: | 26352.14 |
Organism: | Plasmodium falciparum |
Description: | P20035 |
Residue: | 231 |
Sequence: | MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYD
IKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQ
STGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPL
WNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL
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BDBM92357 |
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n/a |
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Name | BDBM92357 |
Synonyms: | HGXPRT Inhibitor, 2 |
Type | Small organic molecule |
Emp. Form. | C9H12N4O4P |
Mol. Mass. | 271.1903 |
SMILES | [O-]P([O-])(=O)CCC[NH2+]c1c[nH]c2c1nc[nH]c2=O |
Structure |
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