| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxanthine-guanine phosphoribosyltransferase |
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| Ligand | BDBM92358 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhbition Assay |
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| pH | 7.6±0 |
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| Temperature | 310.15±0 K |
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| Ki | 385±40 nM |
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| Citation |  Hazleton, KZ; Ho, MC; Cassera, MB; Clinch, K; Crump, DR; Rosario, I; Merino, EF; Almo, SC; Tyler, PC; Schramm, VL Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase. Chem Biol19:721-30 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Hypoxanthine-guanine phosphoribosyltransferase |
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| Name: | Hypoxanthine-guanine phosphoribosyltransferase |
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| Synonyms: | HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
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| Type: | Protein |
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| Mol. Mass.: | 24579.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00492 |
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| Residue: | 218 |
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| Sequence: | MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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| BDBM92358 |
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| n/a |
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| Name | BDBM92358 |
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| Synonyms: | HGXPRT Inhibitor, 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H14N4O5P |
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| Mol. Mass. | 301.2163 |
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| SMILES | OC[C@H](CCP([O-])([O-])=O)[NH2+]c1c[nH]c2c1nc[nH]c2=O |r| |
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| Structure | 
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