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TargetHypoxanthine-guanine phosphoribosyltransferase (HGPRT)
LigandBDBM92358
Substrate/Competitorn/a
Meas. Tech.Inhbition Assay
pH7.6±0
Temperature310.15±0 K
Ki 385±40 nM
Citation Hazleton KZHo MCCassera MBClinch KCrump DRRosario IMerino EFAlmo SCTyler PCSchramm VL Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase. Chem Biol 19:721-30 (2012) [PubMed]  Article
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Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Name:Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Synonyms:HGPRT | HGPRTase | HPRT
Type:Protein
Mol. Mass.:24579.61
Organism:Homo sapiens (Human)
Description:P00492
Residue:218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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  Blast E-value cutoff:
BDBM92358
n/a
NameBDBM92358
Synonyms:HGXPRT Inhibitor, 3
TypeSmall organic molecule
Emp. Form.C10H14N4O5P
Mol. Mass.301.2163
SMILESOC[C@H](CCP([O-])([O-])=O)[NH2+]c1c[nH]c2c1nc[nH]c2=O |r|
Structure
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