| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Pancreatic alpha-amylase |
|---|
| Ligand | BDBM92366 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Activity Assay |
|---|
| pH | 7±0 |
|---|
| Temperature | 310.15±0 K |
|---|
| Ki | 2.04e+5± 7.2e+4 nM |
|---|
| IC50 | 8.89e+4± 6.0e+3 nM |
|---|
| Citation |  Senger, MR; Gomes, Lda C; Ferreira, SB; Kaiser, CR; Ferreira, VF; Silva, FP Kinetics Studies on the Inhibition Mechanism of Pancreatic α-Amylase by Glycoconjugated 1H-1,2,3-Triazoles: A New Class of Inhibitors with Hypoglycemiant Activity. Chembiochem13:1584-93 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Pancreatic alpha-amylase |
|---|
| Name: | Pancreatic alpha-amylase |
|---|
| Synonyms: | 1,4-alpha-D-glucan glucanohydrolase | AMY2 | AMYP_PIG | Pancreatic α-amylase | Pancreatic α-amylase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 57088.07 |
|---|
| Organism: | Sus scrofa (Pig) |
|---|
| Description: | P00690 |
|---|
| Residue: | 511 |
|---|
| Sequence: | MKLFLLLSAFGFCWAQYAPQTQSGRTSIVHLFEWRWVDIALECERYLGPKGFGGVQVSPP
NENIVVTNPSRPWWERYQPVSYKLCTRSGNENEFRDMVTRCNNVGVRIYVDAVINHMCGS
GAAAGTGTTCGSYCNPGNREFPAVPYSAWDFNDGKCKTASGGIESYNDPYQVRDCQLVGL
LDLALEKDYVRSMIADYLNKLIDIGVAGFRIDASKHMWPGDIKAVLDKLHNLNTNWFPAG
SRPFIFQEVIDLGGEAIQSSEYFGNGRVTEFKYGAKLGTVVRKWSGEKMSYLKNWGEGWG
FMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKVAVGFMLAHPYGFTRVMSSYRWA
RNFVNGQDVNDWIGPPNNNGVIKEVTINADTTCGNDWVCEHRWRQIRNMVWFRNVVDGQP
FANWWANGSNQVAFGRGNRGFIVFNNDDWQLSSTLQTGLPGGTYCDVISGDKVGNSCTGI
KVYVSSDGTAQFSISNSAEDPFIAIHAESKL
|
|
|
|---|
| BDBM92366 |
|---|
| n/a |
|---|
| Name | BDBM92366 |
|---|
| Synonyms: | GPESB14 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H15N3O4 |
|---|
| Mol. Mass. | 277.2759 |
|---|
| SMILES | O[C@@H]1O[C@H](Cn2cc(nn2)-c2ccccc2)[C@H](O)C1O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
