| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminyl-peptide cyclotransferase |
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| Ligand | BDBM7887 |
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| Substrate/Competitor | BDBM92450 |
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| Meas. Tech. | Inhibitor Assay |
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| pH | 8±0 |
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| Temperature | 298.15±0 K |
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| Ki | 262± 62 nM |
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| Citation |  Huang, KF; Liaw, SS; Huang, WL; Chia, CY; Lo, YC; Chen, YL; Wang, AH Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. J Biol Chem286:12439-49 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Glutaminyl-peptide cyclotransferase |
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| Name: | Glutaminyl-peptide cyclotransferase |
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| Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 40877.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16769 |
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| Residue: | 361 |
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| Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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| BDBM7887 |
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| BDBM92450 |
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| Name | BDBM7887 |
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| Synonyms: | 1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1-benzylimidazole | CHEMBL14192 | US9138393, 1-benzylimidazole |
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| Type | Small organic molecule |
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| Emp. Form. | C10H10N2 |
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| Mol. Mass. | 158.1998 |
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| SMILES | C(c1ccccc1)n1ccnc1 |
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| Structure | 
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