| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Ligand | BDBM92455 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| pH | 7.5±0 |
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| Temperature | 303.15±0 K |
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| IC50 | 5.0e+2±n/a nM |
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| Citation |  Kukimoto-Niino, M; Yoshikawa, S; Takagi, T; Ohsawa, N; Tomabechi, Y; Terada, T; Shirouzu, M; Suzuki, A; Lee, S; Yamauchi, T; Okada-Iwabu, M; Iwabu, M; Kadowaki, T; Minokoshi, Y; Yokoyama, S Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem286:22570-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Name: | Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Synonyms: | CAMKK2 | CAMKKB | Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKKB) | Calcium/calmodulin-dependent protein kinase kinase beta | KIAA0787 | KKCC2_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 64746.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_27437015 |
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| Residue: | 588 |
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| Sequence: | MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQP
PGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE
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| BDBM92455 |
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| n/a |
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| Name | BDBM92455 |
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| Synonyms: | CHEMBL265470 | STO-609 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H10N2O3 |
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| Mol. Mass. | 314.2943 |
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| SMILES | OC(=O)c1ccc2c3nc4ccccc4n3c(=O)c3cccc1c23 |
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| Structure | 
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