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TargetGenome polyprotein [1027-1206,R1052K]/[1678-1691]
LigandBDBM3894
Substrate/CompetitorNS4B-5A
Meas. Tech.HCV Protease Inhibition Assay
IC50 440±n/a nM
Citation Bailey, MD; Halmos, T; Goudreau, N; Lescop, E; Llinas-Brunet, M Novel azapeptide inhibitors of hepatitis C virus serine protease. J Med Chem47:3788-99 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Genome polyprotein [1027-1206,R1052K]/[1678-1691]
Name:Genome polyprotein [1027-1206,R1052K]/[1678-1691]
Synonyms:HCV NS3-NS4A Serine Proteinase
Type:Enzyme and Cofactor
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Genome polyprotein [1027-1206,R1052K]
Synonyms:HCV NS3 Proteinase | NS3-NS4A Protein | POLG_HCVCO
Type:Enzyme Subunit
Mol. Mass.:18947.03
Organism:Hepatitis C virus
Description:HCV (BK strain) NS3 protein region from amino acid 1 to 180, harboring a C-terminal poly Lys solubilization motif (ASKKKK).
Residue:180
Sequence:
APITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAG
SKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRG
DSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Genome polyprotein [1678-1691]
Synonyms:HCV NS4A | POLG_HCVJA
Type:Peptide
Mol. Mass.:1815.28
Organism:n/a
Description:NS4A-derived peptide
Residue:17
Sequence:
KKGSVVIVGRIILSGRK
 
BDBM3894
NS4B-5A
Name:NS4B-5A
Synonyms:n/a
Type:Peptide
Mol. Mass.:1414.56
Organism:n/a
Description:NS4B-5A derived peptide
Residue:12
Sequence:
DDIVPCSMSYTW