| Reaction Details |
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 | Report a problem with these data |
| Target | Plasminogen activator inhibitor 1 |
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| Ligand | BDBM50041419 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay |
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| pH | 7.8±0 |
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| Temperature | 296.15±0 K |
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| IC50 | 4.4e+3± 3e+2 nM |
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| Citation |  Cale, JM; Li, SH; Warnock, M; Su, EJ; North, PR; Sanders, KL; Puscau, MM; Emal, CD; Lawrence, DA Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1. J Biol Chem285:7892-902 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Plasminogen activator inhibitor 1 |
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| Name: | Plasminogen activator inhibitor 1 |
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| Synonyms: | Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 45064.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05121 |
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| Residue: | 402 |
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| Sequence: | MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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| BDBM50041419 |
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| n/a |
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| Name | BDBM50041419 |
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| Synonyms: | 1,2,5,8-tetrahydroxy-9,10-anthracenedione | 1,2,5,8-tetrahydroxy-9,10-anthraquinone | 1,2,5,8-tetrahydroxyanthra-9,10-quinone | 1,2,5,8-tetrahydroxyanthracene-9,10-dione | 1,2,5,8-tetrahydroxyanthraquinone | 1,4,5,6-tetrahydroxyanthraquinone | Alizarinbordeaux | Alizarine Bordeaux B | CHEMBL29898 | Quinalizarin, E | quinalizarin |
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| Type | Small organic molecule |
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| Emp. Form. | C14H8O6 |
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| Mol. Mass. | 272.2097 |
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| SMILES | Oc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O |
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| Structure | 
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