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TargetPlasminogen activator inhibitor-1
LigandBDBM50041419
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay
pH7.8±0
Temperature296.15±0 K
IC50 4.4e+3± 3e+2 nM
Citation Cale JMLi SHWarnock MSu EJNorth PRSanders KLPuscau MMEmal CDLawrence DA Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1. J Biol Chem 285:7892-902 (2010) [PubMed]  Article
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Plasminogen activator inhibitor-1
Name:Plasminogen activator inhibitor-1
Synonyms:Endothelial plasminogen activator inhibitor | PAI | PAI-1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator-1 (PAI-1)
Type:Enzyme
Mol. Mass.:45064.00
Organism:Homo sapiens (Human)
Description:P05121
Residue:402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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  Blast E-value cutoff:
BDBM50041419
n/a
NameBDBM50041419
Synonyms:1,2,5,8-tetrahydroxy-9,10-anthracenedione | 1,2,5,8-tetrahydroxy-9,10-anthraquinone | 1,2,5,8-tetrahydroxyanthra-9,10-quinone | 1,2,5,8-tetrahydroxyanthracene-9,10-dione | 1,2,5,8-tetrahydroxyanthraquinone | 1,4,5,6-tetrahydroxyanthraquinone | Alizarinbordeaux | Alizarine Bordeaux B | CHEMBL29898 | Quinalizarin, E | quinalizarin
TypeSmall organic molecule
Emp. Form.C14H8O6
Mol. Mass.272.2097
SMILESOc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O
Structure
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