Reaction Details |
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Target | Steroid C26-monooxygenase |
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Ligand | BDBM25817 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Binding Assay |
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Kd | 8.60e+5± 1.08e+5 nM |
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Citation | Driscoll, MD; McLean, KJ; Levy, C; Mast, N; Pikuleva, IA; Lafite, P; Rigby, SE; Leys, D; Munro, AW Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen. J Biol Chem285:38270-82 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Steroid C26-monooxygenase |
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Name: | Steroid C26-monooxygenase |
Synonyms: | CP142_MYCTO | Cytochrome P450 142 | Cytochrome P450 142 (CYP142) | cyp142 |
Type: | Enzyme |
Mol. Mass.: | 41422.72 |
Organism: | Mycobacterium tuberculosis |
Description: | P9WPL4 |
Residue: | 372 |
Sequence: | MRANQPVFRDRNGLAAASTYQAVIDAERQPELFSNAGGIRPDQPALPMMIDMDDPAHLLR
RKLVNAGFTRKRVKDKEASIAALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVRP
EQRDMFLRWSDDLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLV
SSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPSLLPGA
IEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQRN
PNSHLAFGFGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLES
MPVVFTPSPPLG
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BDBM25817 |
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n/a |
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Name | BDBM25817 |
Synonyms: | 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol | CHEMBL106 | Diflucan | Fluconazole | Fluconazole (f) | Fungata | Triflucan | US10221160, Fluconazole | US11247981, Example Fluconazole | US9138393, Fluconazole | US9144538, Fluconazole | US9221791, Fluconazole | US9556143, Fluconazole | cid_3365 |
Type | Small organic molecule |
Emp. Form. | C13H12F2N6O |
Mol. Mass. | 306.2708 |
SMILES | OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F |
Structure |
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