Reaction Details |
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Target | Cytochrome P450 144 |
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Ligand | BDBM50333117 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Binding Assay |
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Kd | 1.74e+5± 1.4e+4 nM |
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Citation | Driscoll, MD; McLean, KJ; Levy, C; Mast, N; Pikuleva, IA; Lafite, P; Rigby, SE; Leys, D; Munro, AW Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen. J Biol Chem285:38270-82 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 144 |
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Name: | Cytochrome P450 144 |
Synonyms: | CP144_MYCTO | Cytochrome P450 144 (CYP144) | cyp144 |
Type: | Enzyme |
Mol. Mass.: | 47207.78 |
Organism: | Mycobacterium tuberculosis |
Description: | P9WPL0 |
Residue: | 434 |
Sequence: | MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDPYPLYERMRAAG
SVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVL
ATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPM
MVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQFDRAAA
DPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQV
RANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFE
APGEFRLDRAGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGWLPS
ILVRRIERLELAVQ
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BDBM50333117 |
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n/a |
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Name | BDBM50333117 |
Synonyms: | (2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol | (2R,3S)-2-(2,4-Difluoro-phenyl)-3-(5-fluoro-pyrimidin-4-yl)-1-[1,2,4]triazol-1-yl-butan-2-ol | (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol | CHEMBL638 | UK-109496 | US11247981, Example Voriconazole | US9221791, Voriconazole | VORICONAZOLE | Vfend |
Type | Small organic molecule |
Emp. Form. | C16H14F3N5O |
Mol. Mass. | 349.3105 |
SMILES | C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F |r| |
Structure |
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