| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 144 |
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| Ligand | BDBM50333117 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| Kd | 1.74e+5± 1.4e+4 nM |
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| Citation |  Driscoll, MD; McLean, KJ; Levy, C; Mast, N; Pikuleva, IA; Lafite, P; Rigby, SE; Leys, D; Munro, AW Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen. J Biol Chem285:38270-82 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 144 |
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| Name: | Cytochrome P450 144 |
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| Synonyms: | CP144_MYCTO | Cytochrome P450 144 (CYP144) | cyp144 |
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| Type: | Enzyme |
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| Mol. Mass.: | 47207.78 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | P9WPL0 |
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| Residue: | 434 |
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| Sequence: | MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDPYPLYERMRAAG
SVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVL
ATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPM
MVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQFDRAAA
DPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQV
RANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFE
APGEFRLDRAGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGWLPS
ILVRRIERLELAVQ
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| BDBM50333117 |
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| n/a |
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| Name | BDBM50333117 |
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| Synonyms: | (2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol | (2R,3S)-2-(2,4-Difluoro-phenyl)-3-(5-fluoro-pyrimidin-4-yl)-1-[1,2,4]triazol-1-yl-butan-2-ol | (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol | CHEMBL638 | UK-109496 | US11247981, Example Voriconazole | US9221791, Voriconazole | VORICONAZOLE | Vfend |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14F3N5O |
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| Mol. Mass. | 349.3105 |
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| SMILES | C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F |r| |
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| Structure | 
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