Reaction Details |
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Target | Glutamine-dependent NAD(+) synthetase |
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Ligand | BDBM92597 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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pH | 8.5±0 |
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Temperature | 310.15±0 K |
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IC50 | 2.48e+4± 1.5e+3 nM |
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Citation | Boshoff, HI; Xu, X; Tahlan, K; Dowd, CS; Pethe, K; Camacho, LR; Park, TH; Yun, CS; Schnappinger, D; Ehrt, S; Williams, KJ; Barry, CE Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli. J Biol Chem283:19329-41 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Glutamine-dependent NAD(+) synthetase |
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Name: | Glutamine-dependent NAD(+) synthetase |
Synonyms: | NAD synthetase | NADE_HUMAN | NADSYN1 |
Type: | Enzyme |
Mol. Mass.: | 79282.89 |
Organism: | Homo sapiens (Human) |
Description: | Q6IA69 |
Residue: | 706 |
Sequence: | MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYES
DTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANE
GNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT
PHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRL
YYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPR
VKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGV
DSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMAS
KNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLA
LQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIG
GISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSV
YGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAE
NYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD
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BDBM92597 |
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n/a |
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Name | BDBM92597 |
Synonyms: | CHEMBL324501 | NAD Synthetase Inhibitor, 2 |
Type | Organic molecule |
Emp. Form. | C34H43N2O3 |
Mol. Mass. | 527.7163 |
SMILES | C[N+](C)(C)c1ccc(CC(=O)OCCCCCCCCn2ccc3cc(OCc4ccccc4)ccc23)cc1 |
Structure |
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