Reaction Details |
| Report a problem with these data |
Target | Glutamine-dependent NAD(+) synthetase |
---|
Ligand | BDBM92599 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Inhibition Assay |
---|
pH | 8.5±0 |
---|
Temperature | 310.15±0 K |
---|
IC50 | 2.18e+4± 1.4e+3 nM |
---|
Citation | Boshoff, HI; Xu, X; Tahlan, K; Dowd, CS; Pethe, K; Camacho, LR; Park, TH; Yun, CS; Schnappinger, D; Ehrt, S; Williams, KJ; Barry, CE Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli. J Biol Chem283:19329-41 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Glutamine-dependent NAD(+) synthetase |
---|
Name: | Glutamine-dependent NAD(+) synthetase |
Synonyms: | NAD synthetase | NADE_HUMAN | NADSYN1 |
Type: | Enzyme |
Mol. Mass.: | 79282.89 |
Organism: | Homo sapiens (Human) |
Description: | Q6IA69 |
Residue: | 706 |
Sequence: | MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYES
DTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANE
GNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT
PHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRL
YYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPR
VKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGV
DSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMAS
KNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLA
LQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIG
GISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSV
YGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAE
NYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD
|
|
|
BDBM92599 |
---|
n/a |
---|
Name | BDBM92599 |
Synonyms: | CHEMBL263057 | NAD Synthetase Inhibitor, 4 |
Type | Organic molecule |
Emp. Form. | C35H43N2O5 |
Mol. Mass. | 571.7258 |
SMILES | COC(=O)c1cc2cc(OCc3ccccc3)ccc2n1CCCCCCCOC(=O)Cc1ccc(cc1)[N+](C)(C)C |
Structure |
|