Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetGlutamine-dependent NAD(+) synthetase
LigandBDBM92599
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH8.5±0
Temperature310.15±0 K
IC50 2.18e+4± 1.4e+3 nM
Citation Boshoff, HIXu, XTahlan, KDowd, CSPethe, KCamacho, LRPark, THYun, CSSchnappinger, DEhrt, SWilliams, KJBarry, CE Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli. J Biol Chem283:19329-41 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Glutamine-dependent NAD(+) synthetase
Name:Glutamine-dependent NAD(+) synthetase
Synonyms:NAD synthetase | NADE_HUMAN | NADSYN1
Type:Enzyme
Mol. Mass.:79282.89
Organism:Homo sapiens (Human)
Description:Q6IA69
Residue:706
Sequence:
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYES
DTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANE
GNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT
PHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRL
YYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPR
VKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGV
DSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMAS
KNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLA
LQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIG
GISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSV
YGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAE
NYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM92599
n/a
NameBDBM92599
Synonyms:CHEMBL263057 | NAD Synthetase Inhibitor, 4
TypeOrganic molecule
Emp. Form.C35H43N2O5
Mol. Mass.571.7258
SMILESCOC(=O)c1cc2cc(OCc3ccccc3)ccc2n1CCCCCCCOC(=O)Cc1ccc(cc1)[N+](C)(C)C
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: