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TargetcGMP-dependent protein kinase
LigandBDBM92607
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
Temperature303.15±0 K
Ki 7.6e+2± 5e+1 nM
Citation Chijiwa TMishima AHagiwara MSano MHayashi KInoue TNaito KToshioka THidaka H Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 265:5267-72 (1990) [PubMed]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
cGMP-dependent protein kinase
Name:cGMP-dependent protein kinase 1 beta
Synonyms:GMP-dependent protein kinase I | Protein Kinase G | cGMP-dependent protein kinase 1
Type:Protein
Mol. Mass.:76358.04
Organism:Homo sapiens (Human)
Description:Q13976
Residue:671
Sequence:
MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTR
AQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMY
PVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTAT
VKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEET
HYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDV
RTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDF
NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF
IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI
IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD
YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS
ERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPP
PDDNSGWDIDF
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  Blast E-value cutoff:
BDBM92607
n/a
NameBDBM92607
Synonyms:H-88
TypeSmall Molecule
Emp. Form.C20H21N3O2S
Mol. Mass.367.465
SMILESO=S(=O)(NCCNC\C=C\c1ccccc1)c1cccc2cnccc12
Structure
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