Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase SYK |
---|
Ligand | BDBM92626 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Syk Enzyme Assay |
---|
pH | 7.4±0 |
---|
Temperature | 298.15±0 K |
---|
IC50 | 2.1±0.0 nM |
---|
Citation | Lovering, F; McDonald, J; Whitlock, GA; Glossop, PA; Phillips, C; Bent, A; Sabnis, Y; Ryan, M; Fitz, L; Lee, J; Chang, JS; Han, S; Kurumbail, R; Thorarensen, A Identification of Type-II Inhibitors Using Kinase Structures. Chem Biol Drug Des80:657-64 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Tyrosine-protein kinase SYK |
---|
Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
|
|
|
BDBM92626 |
---|
n/a |
---|
Name | BDBM92626 |
Synonyms: | Pyrido analog, 3 |
Type | Organic molecule |
Emp. Form. | C29H22F3N5O2 |
Mol. Mass. | 529.5125 |
SMILES | Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O |
Structure |
|