| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein [1658-1692] |
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| Ligand | BDBM92631 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FRET-Based Assay |
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| Temperature | 298.15±0 K |
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| Kd | 24000±n/a nM |
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| Citation |  Saalau-Bethell, SM; Woodhead, AJ; Chessari, G; Carr, MG; Coyle, J; Graham, B; Hiscock, SD; Murray, CW; Pathuri, P; Rich, SJ; Richardson, CJ; Williams, PA; Jhoti, H Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function. Nat Chem Biol8:920-5 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Genome polyprotein [1658-1692] |
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| Name: | Genome polyprotein [1658-1692] |
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| Synonyms: | NS3 Protein | Single chain N-terminally linked NS4a 21-32 NS3 3-631 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Genome polyprotein |
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| Synonyms: | Hepatitis C virus NS3 protease/helicase | Hepatitis C virus serine protease, NS3/NS4A |
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| Type: | Protein |
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| Mol. Mass.: | 67067.41 |
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| Organism: | Hepatitis C virus |
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| Description: | A3EZI9 |
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| Residue: | 631 |
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| Sequence: | APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAG
TRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRG
DGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMR
SPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGA
YMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSI
LGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIK
GGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTG
DFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGE
RPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLT
HIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLY
RLGAVQNEITLTHPITKYIMTCMSADLEVVT
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| Component 2 |
| Name: | Genome polyprotein [1658-1692] |
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| Synonyms: | NS4A Protein | POLG_HCVTW |
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| Type: | Protein |
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| Mol. Mass.: | 3488.19 |
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| Organism: | Hepatitis C virus |
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| Description: | F4YQW6 |
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| Residue: | 35 |
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| Sequence: | STWVLVGGVL AALAAYCLTT GSVVIVGRII LSGKP
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| BDBM92631 |
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| n/a |
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| Name | BDBM92631 |
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| Synonyms: | (3R)-3-{[(1S)-1-(4-chloro-2-fluoro-3-phenoxyphenyl)propyl]amino}butanamide, 7 |
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| Type | Small molecule |
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| Emp. Form. | C19H22ClFN2O2 |
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| Mol. Mass. | 364.842 |
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| SMILES | CC[C@H](N[C@H](C)CC(N)=O)c1ccc(Cl)c(Oc2ccccc2)c1F |r| |
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| Structure | 
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