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Reaction Details
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TargetPeptide deformylase
LigandBDBM92763
Substrate/Competitorn/a
Meas. Tech.Binding Assay
Ki 31720±0.0 nM
Citation Totoritis, RDuraiswami, CTaylor, ANKerrigan, JJCampobasso, NSmith, KJWard, PKing, BWMurrayz-Thompson, MJones, ADVan Aller, GSAubart, KMZalacain, MThrall, SHMeek, TDSchwartz, B Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors. Biochemistry50:6642-54 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peptide deformylase
Name:Peptide deformylase
Synonyms:DEF_STRR6 | PDF | Polypeptide Deformylase | Polypeptide deformylase (PDF) | def
Type:Enzyme
Mol. Mass.:22684.24
Organism:Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Description:The pdf gene from S. pneumoniae was cloned and protein was expressed and purified from E. coli BL21(DE3).
Residue:203
Sequence:
MSAIERITKAAHLIDMNDIIREGNPTLRTVAEEVTFPLSDQEIILGEKMMQFLKHSQDPV
MAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIVEEGETPQEAYDLEAIMYNPKIVSHSVQ
DAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHRIKLKGYNSIVVQHEIDHING
IMFYDRINEKDPFAVKDGLLILE
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  Blast E-value cutoff:
BDBM92763
n/a
NameBDBM92763
Synonyms:PDF inhibitor, compound 5
TypeSmall molecule
Emp. Form.C9H9Cl2NO3
Mol. Mass.250.079
SMILESON(CCOc1cccc(Cl)c1Cl)C=O
Structure
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