Reaction Details |
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Target | Peptide deformylase |
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Ligand | BDBM92766 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Binding Assay |
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Ki | 53.7±0.0 nM |
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Citation | Totoritis, R; Duraiswami, C; Taylor, AN; Kerrigan, JJ; Campobasso, N; Smith, KJ; Ward, P; King, BW; Murrayz-Thompson, M; Jones, AD; Van Aller, GS; Aubart, KM; Zalacain, M; Thrall, SH; Meek, TD; Schwartz, B Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors. Biochemistry50:6642-54 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Peptide deformylase |
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Name: | Peptide deformylase |
Synonyms: | DEF_STRR6 | PDF | Polypeptide Deformylase | Polypeptide deformylase (PDF) | def |
Type: | Enzyme |
Mol. Mass.: | 22684.24 |
Organism: | Streptococcus pneumoniae (strain ATCC BAA-255 / R6) |
Description: | The pdf gene from S. pneumoniae was cloned and protein was expressed and purified from E. coli BL21(DE3). |
Residue: | 203 |
Sequence: | MSAIERITKAAHLIDMNDIIREGNPTLRTVAEEVTFPLSDQEIILGEKMMQFLKHSQDPV
MAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIVEEGETPQEAYDLEAIMYNPKIVSHSVQ
DAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHRIKLKGYNSIVVQHEIDHING
IMFYDRINEKDPFAVKDGLLILE
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BDBM92766 |
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n/a |
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Name | BDBM92766 |
Synonyms: | PDF inhibitor, compound 8 |
Type | Small molecule |
Emp. Form. | C26H31ClN8O3S |
Mol. Mass. | 571.094 |
SMILES | Cc1ccccc1Nc1nc(nc(n1)N1CCN(CC1)c1ccccc1Cl)N1CSC[C@H]1COCC(=O)NO |r| |
Structure |
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