| Reaction Details |
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 | Report a problem with these data |
| Target | Ribosyldihydronicotinamide dehydrogenase [quinone] |
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| Ligand | BDBM92769 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cell Assay |
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| IC50 | >1.0e+4±n/a nM |
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| Citation |  Yan, C; Dufour, M; Siegel, D; Reigan, P; Gomez, J; Shieh, B; Moody, CJ; Ross, D Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems. Biochemistry50:6678-88 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribosyldihydronicotinamide dehydrogenase [quinone] |
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| Name: | Ribosyldihydronicotinamide dehydrogenase [quinone] |
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| Synonyms: | Metallothionein-3 | NMOR2 | NQO2 | NQO2_HUMAN | NRH dehydrogenase [quinone] 2 | NRH:quinone oxidoreductase 2 | QR2 | Quinone reductase 2 | Quinone reductase 2 (NQO2) | Ribosyldihydronicotinamide dehydrogenase [quinone] |
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| Type: | Protein |
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| Mol. Mass.: | 25917.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P16083 |
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| Residue: | 231 |
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| Sequence: | MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL
SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV
LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC
GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
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| BDBM92769 |
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| n/a |
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| Name | BDBM92769 |
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| Synonyms: | Indolequinone, compd 3 |
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| Type | Small molecule |
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| Emp. Form. | C21H22F3N3O3 |
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| Mol. Mass. | 421.4129 |
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| SMILES | Cc1c(COc2c(F)cc(F)cc2F)c2c(O)cc(N=CCCCN)c(O)c2n1C |w:19.19| |
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| Structure | 
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