Reaction Details |
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Target | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
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Ligand | BDBM92779 |
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Substrate/Competitor | n/a |
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Meas. Tech. | CYP27B1 Inhibition Assay |
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Ki | 1.52e+3± 2.8e+2 nM |
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Citation | Zhu, J; Barycki, R; Chiellini, G; Deluca, HF Screening of selective inhibitors of 1a,25-dihydroxyvitamin D3 24-hydroxylase using recombinant human enzyme expressed in Escherichia coli. Biochemistry49:10403-11 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
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Name: | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
Synonyms: | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | CP27B_HUMAN | CYP1ALPHA | CYP27B | CYP27B1 | Cytochrome P450 27B1 |
Type: | Protein |
Mol. Mass.: | 56522.50 |
Organism: | Homo sapiens (Human) |
Description: | O15528 |
Residue: | 508 |
Sequence: | MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR
LHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCR
QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPP
ALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH
WLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFRE
ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS
ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPA
QFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP
EPGAAPVRPKTRTVLVPERSINLQFLDR
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BDBM92779 |
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n/a |
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Name | BDBM92779 |
Synonyms: | TS17 |
Type | Small molecule |
Emp. Form. | C31H44O4S |
Mol. Mass. | 512.744 |
SMILES | C[C@@H](CCCOS(=O)(=O)c1ccc(C)cc1)C1CCC2\C(CCC[C@]12C)=C\C=C1\C[C@H](O)CCC1=C |r| |
Structure |
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