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Target25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
LigandBDBM92779
Substrate/Competitorn/a
Meas. Tech.CYP27B1 Inhibition Assay
Ki 1.52e+3± 2.8e+2 nM
Citation Zhu, JBarycki, RChiellini, GDeluca, HF Screening of selective inhibitors of 1a,25-dihydroxyvitamin D3 24-hydroxylase using recombinant human enzyme expressed in Escherichia coli. Biochemistry49:10403-11 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Name:25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Synonyms:25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | CP27B_HUMAN | CYP1ALPHA | CYP27B | CYP27B1 | Cytochrome P450 27B1
Type:Protein
Mol. Mass.:56522.50
Organism:Homo sapiens (Human)
Description:O15528
Residue:508
Sequence:
MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR
LHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCR
QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPP
ALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH
WLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFRE
ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS
ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPA
QFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP
EPGAAPVRPKTRTVLVPERSINLQFLDR
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  Blast E-value cutoff:
BDBM92779
n/a
NameBDBM92779
Synonyms:TS17
TypeSmall molecule
Emp. Form.C31H44O4S
Mol. Mass.512.744
SMILESC[C@@H](CCCOS(=O)(=O)c1ccc(C)cc1)C1CCC2\C(CCC[C@]12C)=C\C=C1\C[C@H](O)CCC1=C |r|
Structure
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