Reaction Details |
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Target | Aurora kinase A |
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Ligand | BDBM92831 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Enzyme Assay |
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IC50 | 44.9±4.7 nM |
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Citation | Lawrence, HR; Martin, MP; Luo, Y; Pireddu, R; Yang, H; Gevariya, H; Ozcan, S; Zhu, JY; Kendig, R; Rodriguez, M; Elias, R; Cheng, JQ; Sebti, SM; Schonbrunn, E; Lawrence, NJ Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors. J Med Chem55:7392-416 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase A |
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Name: | Aurora kinase A |
Synonyms: | AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 45830.98 |
Organism: | Homo sapiens (Human) |
Description: | O14965 |
Residue: | 403 |
Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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BDBM92831 |
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n/a |
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Name | BDBM92831 |
Synonyms: | Bisanilinopyrimidine, 9d | US9249124, 47 |
Type | Small molecule |
Emp. Form. | C17H15ClN4O2S |
Mol. Mass. | 374.845 |
SMILES | CS(=O)(=O)c1ccc(Nc2nccc(Nc3ccccc3Cl)n2)cc1 |
Structure |
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