Reaction Details |
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Target | Isochorismatase family protein |
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Ligand | BDBM50026863 |
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Substrate/Competitor | n/a |
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Meas. Tech. | GDH-Coupled Nicotinamidase Assay |
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Ki | 11±1 nM |
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Citation | French, JB; Cen, Y; Vrablik, TL; Xu, P; Allen, E; Hanna-Rose, W; Sauve, AA Characterization of nicotinamidases: steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism. Biochemistry49:10421-39 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Isochorismatase family protein |
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Name: | Isochorismatase family protein |
Synonyms: | Nicotinamidase (SpNic) | Pyrazinamidase/nicotinamidase |
Type: | Enzyme |
Mol. Mass.: | 21361.69 |
Organism: | Streptococcus pneumoniae |
Description: | A0A098ZGI7 |
Residue: | 191 |
Sequence: | MTKALISIDYTEDFVADSGKLTAGAPAQAISDAISKVTRLAFERGDYIFFTIDAHEENDC
FHPESKLFPPHNLIGTSGRNLYGDLGIFYQEHGSDSRVFWMDKRHYSAFSGTDLDIRLRE
RRVSTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVASIWPENHQFALGHFKNTLGAK
LVDENLNELSE
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BDBM50026863 |
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n/a |
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Name | BDBM50026863 |
Synonyms: | CHEMBL268493 | Nicotinamidase Inhibitor, 16 | PncA Inhibitor, 2 | Pyridine-3-carbaldehyde |
Type | Small organic molecule |
Emp. Form. | C6H5NO |
Mol. Mass. | 107.11 |
SMILES | O=Cc1cccnc1 |
Structure |
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