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TargetDihydrolipoyl dehydrogenase
LigandBDBM92887
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay
IC50 1.5e+3±n/a nM
Citation Bryk, RArango, NVenugopal, AWarren, JDPark, YHPatel, MSLima, CDNathan, C Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase . Biochemistry49:1616-27 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrolipoyl dehydrogenase
Name:Dihydrolipoyl dehydrogenase
Synonyms:Component of peroxynitrite reductase/peroxidase complex | DLDH_MYCTO | Dihydrolipoyl dehydrogenase (Lpd) | Dihydrolipoyl dehydrogenase (Lpd) A181V | Dihydrolipoyl dehydrogenase (Lpd) A290R | Dihydrolipoyl dehydrogenase (Lpd) F269R | Dihydrolipoyl dehydrogenase (Lpd) G312A, L313G, L314P, Q315M | Dihydrolipoyl dehydrogenase (Lpd) L314P | Dihydrolipoyl dehydrogenase (Lpd) N209V | Dihydrolipoyl dehydrogenase (Lpd) R147T | Dihydrolipoyl dehydrogenase (Lpd) R347S | Lipoamide dehydrogenase (Lpd) | lpd | lpdC
Type:Enzyme
Mol. Mass.:49231.98
Organism:Mycobacterium tuberculosis
Description:P9WHH8
Residue:464
Sequence:
MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELVH
IFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKNKITEIHGYGTFADANT
LLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAG
AIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIAD
GGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIGVDDYMRTN
VGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDHRMLPRATFCQPNVASFGL
TEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVADAKHGELLGGHLVGHDVAELL
PELTLAQRWDLTASELARNVHTHPTMSEALQECFHGLVGHMINF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM92887
n/a
NameBDBM92887
Synonyms:Triazaspirobenzyl, 5
TypeSmall molecule
Emp. Form.C32H34Cl2N4O5
Mol. Mass.625.542
SMILESCOc1ccc(C(=O)N2CCC3(CC2)N(CN(CC(=O)NCCc2ccc(Cl)cc2Cl)C3=O)c2ccccc2)c(OC)c1
Structure
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