| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein |
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| Ligand | BDBM92896 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Competitive Inhibition Assay |
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| Ki | 290±100 nM |
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| Citation |  Dahl, G; Arenas, OG; Danielson, UH Hepatitis C virus NS3 protease is activated by low concentrations of protease inhibitors. Biochemistry48:11592-602 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein |
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| Name: | Genome polyprotein |
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| Synonyms: | NS3 protein |
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| Type: | Protein |
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| Mol. Mass.: | 45665.89 |
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| Organism: | Hepatitis C virus |
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| Description: | Q04045 |
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| Residue: | 428 |
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| Sequence: | VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYM
SKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILG
IGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGG
RHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDF
DSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERP
SGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHI
DAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRL
GAVQNEVT
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| BDBM92896 |
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| n/a |
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| Name | BDBM92896 |
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| Synonyms: | NS3 Protease Inhibitor, 7 |
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| Type | Small molecule |
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| Emp. Form. | C46H49N5O9S |
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| Mol. Mass. | 847.974 |
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| SMILES | COc1ccc2c(Oc3ccc(cc3)[C@H](NC(=O)C(NC(=O)OC(C)(C)C)C(C)C)C(=O)N[C@@]3(CC3C=C)C(=O)NS(=O)(=O)c3ccccc3)cc(nc2c1)-c1ccccc1 |r| |
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| Structure | 
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