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TargetSerine/threonine-protein kinase Chk1
LigandBDBM92907
Substrate/Competitorn/a
Meas. Tech.CHK1 Inhibition Assay
pH7.4±0
Temperature295.15±0 K
Ki 1.89e+3± 3.2e+2 nM
Citation Vanderpool DJohnson TOPing CBergqvist SAlton GPhonephaly SRui ELuo CDeng YLGrant SQuenzer TMargosiak SRegister JBrown EErmolieff J Characterization of the CHK1 allosteric inhibitor binding site. Biochemistry 48:9823-30 (2009) [PubMed]  Article
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Serine/threonine-protein kinase Chk1
Name:Serine/threonine-protein kinase Chk1/2
Synonyms:CHK1 checkpoint homolog | Checkpoint kinase-1 (CHK1) | Serine/threonine-protein kinase Chk1
Type:Enzyme Catalytic Domain
Mol. Mass.:54443.02
Organism:Homo sapiens (Human)
Description:gi_166295192
Residue:476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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  Blast E-value cutoff:
BDBM92907
n/a
NameBDBM92907
Synonyms:CHK1 compound 2
TypeSmall molecule
Emp. Form.C16H13Cl2N3O2
Mol. Mass.350.199
SMILESCC(OC(=O)Nc1ccc(Cl)c(Cl)c1)c1nc2ccccc2[nH]1
Structure
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