Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM92906 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Surface Plasmon Resonance BindingAssay |
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pH | 8±0 |
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Temperature | 293.15±0 K |
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Ki | 5.14±0.38 nM |
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Citation | Vanderpool, D; Johnson, TO; Ping, C; Bergqvist, S; Alton, G; Phonephaly, S; Rui, E; Luo, C; Deng, YL; Grant, S; Quenzer, T; Margosiak, S; Register, J; Brown, E; Ermolieff, J Characterization of the CHK1 allosteric inhibitor binding site. Biochemistry48:9823-30 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM92906 |
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n/a |
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Name | BDBM92906 |
Synonyms: | CHK1 compound 1 |
Type | Small mnolecule |
Emp. Form. | C25H23N5O5 |
Mol. Mass. | 473.4806 |
SMILES | O[C@H]1CN(C[C@H]1O)C(=O)c1[nH]c2cc(NC(=O)C3C[C@H]3c3ccccc3)cc3c2c1cn[nH]c3=O |r| |
Structure |
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