| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM92939 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| Ki | 11.8±1.8 nM |
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| Citation |  Genis, C; Sippel, KH; Case, N; Cao, W; Avvaru, BS; Tartaglia, LJ; Govindasamy, L; Tu, C; Agbandje-McKenna, M; Silverman, DN; Rosser, CJ; McKenna, R Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties. Biochemistry48:1322-31 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM92939 |
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| n/a |
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| Name | BDBM92939 |
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| Synonyms: | Methazolamide, MZM |
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| Type | Small molecule |
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| Emp. Form. | C6H9N3O3S2 |
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| Mol. Mass. | 235.284 |
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| SMILES | CC1N=C(S\C1=N\C(C)=O)S(N)(=O)=O |c:2| |
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| Structure | 
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