| Reaction Details |
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 | Report a problem with these data |
| Target | Farnesyl pyrophosphate synthase |
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| Ligand | BDBM50059860 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Transferase Assay |
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| Ki | 5.2± 0.7 nM |
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| Citation |  Pompliano, DL; Rands, E; Schaber, MD; Mosser, SD; Anthony, NJ; Gibbs, JB Steady-state kinetic mechanism of Ras farnesyl:protein transferase. Biochemistry31:3800-7 (1992) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Farnesyl pyrophosphate synthase |
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| Name: | Farnesyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48272.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14324 |
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| Residue: | 419 |
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| Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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| BDBM50059860 |
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| n/a |
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| Name | BDBM50059860 |
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| Synonyms: | ((2E,6E)-1-Hydroxy-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-phosphonic acid | CHEMBL26180 | Hydroxy phosphonate, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H27O4P |
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| Mol. Mass. | 302.3462 |
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| SMILES | [#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])-[#6]-[#6](=O)P([#8])([#8])=O |
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| Structure | 
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