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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | DNA gyrase subunit A | ||
| Ligand | BDBM93040 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Assay | ||
| IC50 | 1.00e+5±n/a nM | ||
| Citation |  Karkare, S; Chung, TT; Collin, F; Mitchenall, LA; McKay, AR; Greive, SJ; Meyer, JJ; Lall, N; Maxwell, A The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. J Biol Chem288:5149-56 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| DNA gyrase subunit A | |||
| Name: | DNA gyrase subunit A | ||
| Synonyms: | GYRA_MYCTU | Type IIA topoisomerase subunit GyrA | gyrA | ||
| Type: | Protein | ||
| Mol. Mass.: | 92261.11 | ||
| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | ||
| Description: | P9WG47 | ||
| Residue: | 838 | ||
| Sequence: |
| ||
| BDBM93040 | |||
| n/a | |||
| Name | BDBM93040 | ||
| Synonyms: | Isodiospyrin | MAR-UNI-c84db004-17 | ||
| Type | Small molecule | ||
| Emp. Form. | C22H14O6 | ||
| Mol. Mass. | 374.343 | ||
| SMILES | Cc1cc(O)c2C(=O)C=CC(=O)c2c1-c1c(C)cc2C(=O)C=CC(=O)c2c1O |c:8,23,(4.47,.97,;5.81,1.74,;5.81,3.28,;7.14,4.05,;7.14,5.59,;8.47,3.28,;9.85,4.1,;9.83,5.64,;11.25,3.31,;11.25,1.71,;9.85,.92,;9.85,-.58,;8.47,1.74,;7.14,.97,;7.14,-.57,;8.47,-1.34,;9.81,-2.11,;8.47,-2.88,;7.14,-3.65,;7.16,-5.25,;8.51,-6.01,;5.78,-6.07,;4.39,-5.26,;4.4,-3.66,;3.08,-2.88,;5.81,-2.88,;5.81,-1.34,;4.47,-.57,)| | ||
| Structure | 
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