Reaction Details |
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Target | DNA gyrase subunit A |
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Ligand | BDBM93041 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Assay |
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IC50 | >2.00e+5±n/a nM |
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Citation | Karkare, S; Chung, TT; Collin, F; Mitchenall, LA; McKay, AR; Greive, SJ; Meyer, JJ; Lall, N; Maxwell, A The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. J Biol Chem288:5149-56 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA gyrase subunit A |
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Name: | DNA gyrase subunit A |
Synonyms: | GYRA_MYCTU | Type IIA topoisomerase subunit GyrA | gyrA |
Type: | Protein |
Mol. Mass.: | 92261.11 |
Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Description: | P9WG47 |
Residue: | 838 |
Sequence: | MTDTTLPPDDSLDRIEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMF
DSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPG
NDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGG
IAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGT
ADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGIS
NIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQ
LIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAG
LIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVR
DELAEIVDRHGDDRRTRIIAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRG
GKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRVYRAKAYDLPEASRTARGQHVANLL
AFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELV
GAVLCSAGDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREG
TYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSG
GGVIRTAARQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN
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BDBM93041 |
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n/a |
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Name | BDBM93041 |
Synonyms: | Shinanolone |
Type | Small molecule |
Emp. Form. | C11H12O3 |
Mol. Mass. | 192.2112 |
SMILES | C[C@@H]1CC(=O)c2c(O)cccc2[C@@H]1O |
Structure |
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