| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Anthranilate phosphoribosyltransferase |
|---|
| Ligand | BDBM93079 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluoresence-based Assay |
|---|
| Ki | 7.9e+4± 1.7e+4 nM |
|---|
| Citation |  Castell, A; Short, FL; Evans, GL; Cookson, TV; Bulloch, EM; Joseph, DD; Lee, CE; Parker, EJ; Baker, EN; Lott, JS The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry52:1776-1787 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Anthranilate phosphoribosyltransferase |
|---|
| Name: | Anthranilate phosphoribosyltransferase |
|---|
| Synonyms: | Anthranilate phosphoribosyltransferase (Mtb-AnPRT) | TRPD_MYCTO | trpD |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 37738.87 |
|---|
| Organism: | Mycobacterium tuberculosis |
|---|
| Description: | P9WFX4 |
|---|
| Residue: | 370 |
|---|
| Sequence: | MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPA
QIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLST
MAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAP
RFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSS
VLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAA
VRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLL
ARWVRFGRQI
|
|
|
|---|
| BDBM93079 |
|---|
| n/a |
|---|
| Name | BDBM93079 |
|---|
| Synonyms: | ACS No 165 |
|---|
| Type | Small molecule |
|---|
| Emp. Form. | C12H15N4O6 |
|---|
| Mol. Mass. | 311.2712 |
|---|
| SMILES | NC(CCCNc1ccc(cc1N(=O)=O)[N+]([O-])=O)CC([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
