Reaction Details |
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Target | Prostaglandin G/H synthase 1 [582-599] |
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Ligand | BDBM11639 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro COX Inhibition Assay |
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IC50 | 2.43e+4± 1.6e+3 nM |
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Citation | Zarghi, A; Arefi, H; Dadrass, OG; Torabi, S Design and synthesis of new 2-aryl, 3-benzyl- (1,3-oxazolidine or 1,3-thiazolidine)-4-ones as selective cyclooxygenase (COX-2) inhibitor Med Chem Res19:782-793 (2009) |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin G/H synthase 1 [582-599] |
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Name: | Prostaglandin G/H synthase 1 [582-599] |
Synonyms: | COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH synthase 1 | PGH1_HUMAN | PGHS-1 | PHS 1 | PTGS1 | Prostaglandin G/H synthase 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 |
Type: | Protein |
Mol. Mass.: | 1879.89 |
Organism: | Homo sapiens (Human) |
Description: | Q6LCE7 |
Residue: | 18 |
Sequence: | |
BDBM11639 |
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n/a |
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Name | BDBM11639 |
Synonyms: | 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide | CHEMBL118 | CLX | Celebrex | Celecoxib | US10322118, Urea-Based Scaffold Entry 9 | US11478464, Compound Celecoxib | US11786535, Compound Celecoxib | US8741944, Comparative Compound | US9388139, Celecoxib | cid_2662 |
Type | Small organic molecule |
Emp. Form. | C17H14F3N3O2S |
Mol. Mass. | 381.372 |
SMILES | Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F |
Structure |
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