BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetProstaglandin G/H synthase 1 [582-599]
LigandBDBM11639
Substrate/Competitorn/a
Meas. Tech.In Vitro COX Inhibition Assay
IC50 2.43e+4± 1.6e+3 nM
Citation Zarghi, AArefi, HDadrass, OGTorabi, S Design and synthesis of new 2-aryl, 3-benzyl- (1,3-oxazolidine or 1,3-thiazolidine)-4-ones as selective cyclooxygenase (COX-2) inhibitor Med Chem Res19:782-793 (2009)  
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin G/H synthase 1 [582-599]
Name:Prostaglandin G/H synthase 1 [582-599]
Synonyms:COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH synthase 1 | PGH1_HUMAN | PGHS-1 | PHS 1 | PTGS1 | Prostaglandin G/H synthase 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1
Type:Protein
Mol. Mass.:1879.89
Organism:Homo sapiens (Human)
Description:Q6LCE7
Residue:18
Sequence:
PDASQDDGPAVERPSTEL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM11639
n/a
NameBDBM11639
Synonyms:4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide | CHEMBL118 | CLX | Celebrex | Celecoxib | US10322118, Urea-Based Scaffold Entry 9 | US11478464, Compound Celecoxib | US11786535, Compound Celecoxib | US8741944, Comparative Compound | US9388139, Celecoxib | cid_2662
TypeSmall organic molecule
Emp. Form.C17H14F3N3O2S
Mol. Mass.381.372
SMILESCc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: