| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
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| Ligand | BDBM93116 |
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| Substrate/Competitor | BDBM24514 |
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| Meas. Tech. | In Vitro Assay |
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| pH | 7±0 |
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| Ki | 6.3e+4±n/a nM |
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| IC50 | 8.8e+4±n/a nM |
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| Citation |  Maurya, R; Gupta, P; Ahmad, G; Yadav, DK; Chand, K; Singh, AB; Tamrakar, AK; Srivastava, AK Synthesis of 3,5-disubstituted isoxazolines as protein tyrosine phosphatase 1B inhibitors Medicinal Chemistry Research17:123-136 (2008) |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 1 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
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| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 49963.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant GST-fusion PTP1B (1-435). |
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| Residue: | 435 |
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| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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| BDBM93116 |
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| BDBM24514 |
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| Name | BDBM93116 |
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| Synonyms: | PTP1B Inhibitor, 14 |
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| Type | Small molecule |
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| Emp. Form. | C14H13N3O3 |
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| Mol. Mass. | 271.2713 |
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| SMILES | COc1cc(C=O)ccc1C1=NOC(C1)n1ccnc1 |t:11| |
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| Structure | 
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