| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta |
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| Ligand | BDBM93227 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| IC50 | 2.5e+4±n/a nM |
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| Citation |  Urich, R; Wishart, G; Kiczun, M; Richters, A; Tidten-Luksch, N; Rauh, D; Sherborne, B; Wyatt, PG; Brenk, R De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments. ACS Chem Biol8:1044-52 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta |
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| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
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| Type: | Enzyme |
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| Mol. Mass.: | 46756.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49841 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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| BDBM93227 |
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| n/a |
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| Name | BDBM93227 |
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| Synonyms: | Kinase inhibitor, C2 |
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| Type | Small molecule |
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| Emp. Form. | C14H12N2O3S |
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| Mol. Mass. | 288.322 |
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| SMILES | COc1ccc(cc1OC)-c1cc2c(nc[nH]c2=O)s1 |
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| Structure | 
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