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TargetHypoxia-inducible factor prolyl hydroxylase 1
LigandBDBM93422
Substrate/Competitorn/a
Meas. Tech.PHD Enzymatic Assay
IC50 4.3±0.0 nM
Citation Murray JKBalan CAllgeier AMKasparian AViswanadhan VWilde CAllen JRYoder SCBiddlecome GHungate RWMiranda LP Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1a prolyl hydroxylases-1, -2, and -3 with altered selectivity. J Comb Chem 12:676-86 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hypoxia-inducible factor prolyl hydroxylase 1
Name:Hypoxia-inducible factor prolyl hydroxylase
Synonyms:Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1)
Type:Protein
Mol. Mass.:43657.01
Organism:Homo sapiens (Human)
Description:Q96KS0
Residue:407
Sequence:
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAG
SGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRK
WAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALD
YIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQI
AWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDN
PHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEV
KPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
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  Blast E-value cutoff:
BDBM93422
n/a
NameBDBM93422
Synonyms:PHD Inhibitor, 12{1,1,2}
TypeSmall molecule
Emp. Form.C38H37N5O8
Mol. Mass.691.7291
SMILESCC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1 |r|
Structure
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