| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial PAS domain-containing protein 1 |
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| Ligand | BDBM93990 |
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| Substrate/Competitor | n/a |
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| IC50 | 344±n/a nM |
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| Citation |  PubChem, PC Dose response confirmation of uHTS identification of HIF-2a Inhibitors in a luminesence assay PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article |
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| Endothelial PAS domain-containing protein 1 |
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| Name: | Endothelial PAS domain-containing protein 1 |
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| Synonyms: | BHLHE73 | EPAS1 | EPAS1_HUMAN | HIF2A | MOP2 | PASD2 | endothelial PAS domain-containing protein 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 96453.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1506501 |
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| Residue: | 870 |
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| Sequence: | MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA
ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG
LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG
RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD
SKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
SLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQN
FEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCS
TPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDF
QLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE
HRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTE
FLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQ
DLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHL
PLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELT
RYDCEVNVPVLGSSTLLQGGDLLRALDQAT
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| BDBM93990 |
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| n/a |
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| Name | BDBM93990 |
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| Synonyms: | 3-[2-(4-chlorophenyl)-5,7-dimethyl-6-pyrazolo[1,5-a]pyrimidinyl]-N-(4-methyl-2-thiazolyl)propanamide | 3-[2-(4-chlorophenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]-N-(4-methyl-1,3-thiazol-2-yl)propanamide | 3-[2-(4-chlorophenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]-N-(4-methylthiazol-2-yl)propionamide | 3-[2-(4-chlorophenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]-N-(4-methyl-1,3-thiazol-2-yl)propanamide | MLS000586822 | SMR000208752 | cid_15945494 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20ClN5OS |
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| Mol. Mass. | 425.934 |
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| SMILES | Cc1csc(NC(=O)CCc2c(C)nc3cc(nn3c2C)-c2ccc(Cl)cc2)n1 |
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| Structure | 
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