| Reaction Details |
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 | Report a problem with these data |
| Target | Corticotropin-releasing factor-binding protein |
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| Ligand | BDBM89949 |
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| Substrate/Competitor | n/a |
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| IC50 | 2580±n/a nM |
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| Citation |  PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article |
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| Corticotropin-releasing factor-binding protein |
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| Name: | Corticotropin-releasing factor-binding protein |
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| Synonyms: | CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 36143.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24387 |
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| Residue: | 322 |
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| Sequence: | MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRC
LDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKG
EKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNL
FPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGI
GDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQ
LEPYELENPNGNSIGEFCLSGL
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| BDBM89949 |
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| n/a |
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| Name | BDBM89949 |
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| Synonyms: | 3,3,3-trifluoro-2-[(5-nosylthiazol-2-yl)amino]-2-(p-anisoylamino)propionic acid methyl ester | 3,3,3-trifluoro-2-[[(4-methoxyphenyl)-oxomethyl]amino]-2-[[5-(4-nitrophenyl)sulfonyl-2-thiazolyl]amino]propanoic acid methyl ester | MLS000325345 | SMR000163417 | cid_5103080 | methyl 3,3,3-trifluoro-2-[(4-methoxybenzoyl)amino]-2-[[5-(4-nitrophenyl)sulfonyl-1,3-thiazol-2-yl]amino]propanoate | methyl 3,3,3-trifluoro-2-{[5-({4-nitrophenyl}sulfonyl)-1,3-thiazol-2-yl]amino}-2-[(4-methoxybenzoyl)amino]propanoate | methyl 3,3,3-tris(fluoranyl)-2-[(4-methoxyphenyl)carbonylamino]-2-[[5-(4-nitrophenyl)sulfonyl-1,3-thiazol-2-yl]amino]propanoate |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17F3N4O8S2 |
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| Mol. Mass. | 574.507 |
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| SMILES | COC(=O)C(NC(=O)c1ccc(OC)cc1)(Nc1ncc(s1)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O)C(F)(F)F |
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| Structure | 
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