Ki Summary

Reaction Details

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Target

Corticotropin-releasing factor-binding protein

Ligand

BDBM90269

Substrate/Competitor

n/a

IC50

2360±n/a nM

Citation

PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay(2012)[AID]

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Corticotropin-releasing factor-binding protein

Name:

Corticotropin-releasing factor-binding protein

Synonyms:

CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

36143.95

Organism:

Homo sapiens (Human)

Description:

P24387

Residue:

322

Sequence:

MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRC
LDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKG
EKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNL
FPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGI
GDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQ
LEPYELENPNGNSIGEFCLSGL

BDBM90269

n/a

Name

BDBM90269

Synonyms:

3-[2-[1-(1,3-benzodioxol-5-yl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl]-5-methyl-5-(2-methylpropyl)imidazolidine-2,4-dione | 3-[2-[1-(1,3-benzodioxol-5-yl)-2,5-dimethyl-pyrrol-3-yl]-2-keto-ethyl]-5-isobutyl-5-methyl-hydantoin | 3-[2-[1-(1,3-benzodioxol-5-yl)-2,5-dimethyl-pyrrol-3-yl]-2-oxidanylidene-ethyl]-5-methyl-5-(2-methylpropyl)imidazolidine-2,4-dione | 3-[2-[1-(1,3-benzodioxol-5-yl)-2,5-dimethylpyrrol-3-yl]-2-oxoethyl]-5-methyl-5-(2-methylpropyl)imidazolidine-2,4-dione | MLS000388825 | SMR000254998 | cid_15945261

Type

Small organic molecule

Emp. Form.

C23H27N3O5

Mol. Mass.

425.4776

SMILES

CC(C)CC1(C)NC(=O)N(CC(=O)c2cc(C)n(c2C)-c2ccc3OCOc3c2)C1=O

Structure