| Reaction Details |
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 | Report a problem with these data |
| Target | Hepatocyte nuclear factor 4-alpha |
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| Ligand | BDBM43474 |
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| Substrate/Competitor | n/a |
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| IC50 | 12884±n/a nM |
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| Citation |  PubChem, PC Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article |
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| Hepatocyte nuclear factor 4-alpha |
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| Name: | Hepatocyte nuclear factor 4-alpha |
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| Synonyms: | HNF4 | HNF4A | HNF4A_HUMAN | NR2A1 | TCF14 | hepatocyte nuclear factor 4-alpha isoform b |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52790.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_606516 |
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| Residue: | 474 |
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| Sequence: | MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC
AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC
FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK
IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK
DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK
GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL
FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW
PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
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| BDBM43474 |
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| n/a |
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| Name | BDBM43474 |
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| Synonyms: | (3Z,5E)-1-ethyl-3,5-bis(3-hydroxy-4-methoxy-benzylidene)-4-piperidone | (3Z,5E)-1-ethyl-3,5-bis[(3-hydroxy-4-methoxyphenyl)methylidene]-4-piperidinone | (3Z,5E)-1-ethyl-3,5-bis[(3-hydroxy-4-methoxyphenyl)methylidene]piperidin-4-one | (3Z,5E)-1-ethyl-3,5-bis[(4-methoxy-3-oxidanyl-phenyl)methylidene]piperidin-4-one | MLS000775870 | SMR000371004 | cid_2376815 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25NO5 |
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| Mol. Mass. | 395.4483 |
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| SMILES | CCN1C\C(=C\c2ccc(OC)c(O)c2)C(=O)\C(C1)=C\c1ccc(OC)c(O)c1 |
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| Structure | 
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